2020 AACBS Annual General Meeting and Scientific Meeting will be hosted online in September 2020. Stay tuned!                        


Dr Yan-Chuan Shi


Dr Yanchuan Shi, MD (AMC), PhD (UNSW)                                              

Group Leader, Neuroendocrinology Group

Eating Disorders Research Lab

Neuroscience Division                                                                                  

Garvan Institute of Medical Research

Conjoint Senior Lecturer, St Vincent's Clinical School,

Faculty of Medicine, UNSW Australia                                                                  


Ph:  +61 2 9295 8530 (office) or +61 2 92958301 (lab)





I obtained my PhD from University of New South Wales (UNSW) in 2006 at the Garvan Institute of Medical Research, Sydney, and have been working in the field of obesity and diabetes research for more than 10 years. By employing unique germline and conditional knockout/knockin/overexpressing mouse models and sophisticated molecular and cellular techniques, my primary interest is to understand how centrally- and peripherally- produced neuropeptide Y (NPY), PYY and PP and their receptors (Y1, Y2, Y4 & Y5) integrate neuronal and hormonal signals to control appetite, energy expenditure, adipose tissue metabolism, beige cell formation, beta cell function and glucose homeostasis. From 2012, I have expanded my research interests to include the understanding of the impact of islet-specific PYY and its receptors in modulating beta cell function, insulin secretion as well as underlying mechanisms. In 2014 I was promoted to the Group leader of Neuroendocrinology within the Neuroscience Division.

Originally trained as a medical doctor who successfully re-qualified for a medical license (set out by Australian Medical Council, AMC) in Australia in 2012, my deep understanding of obesity and diabetes has provided me with a unique advantage, enabling me to translate basic science findings into the clinical setting. My research has been supported by the grants from Diabetes Australia Research Trust (DART) and National Health Medical Research Council (NHMRC). Research results have been published on prestigious peer-reviewed top-ranked journals such as Cell Metabolism, Nature Communications, Trends in Endocrinology & Metabolism, Molecular Metabolism, Scientific Reports and Obesity in which I am either first author or corresponding author.


I am currently recruiting PhD students, honor students, UROP students and visiting scholars from overseas. If you are interested in any aspects of my research, please feel free to contact me via the email listed above.